Effect of wheat-grain moxibustion on the expression of Beclin-1/GRP78 in spinal dorsal horn in rats with cervical spondylotic radiculopathy / 中国针灸

OBJECTIVE@#To observe the effect of wheat-grain moxibustion at "Dazhui" (GV 14) on the expressions of Beclin-1 and GRP78 in spinal dorsal horn in rats with cervical spondylotic radiculopathy (CSR), and to explore the possible analgesic mechanism of wheat-grain moxibustion for CSR.@*METHODS@#A total of 48 SD rats were randomly divided into a sham operation group, a model group, a wheat-grain moxibustion group and a wheat-grain moxibustion+3-MA group, 12 rats in each group. The CSR model was prepared by spinal cord insertion method. Three days after modeling, the rats in the model group were intraperitoneally injected with 1 mL of 0.9% sodium chloride solution; the rats in the wheat-grain moxibustion group were treated with wheat-grain moxibustion at "Dazhui" (GV 14, 6 cones per time) on the basis of the model group; the rats in the wheat-grain moxibustion+3-MA group were intraperitoneally injected with 3-MA solution and wheat-grain moxibustion at "Dazhui" (GV 14, 6 cones per time). The three groups were intervened for 7 days, once a day. The gait score and mechanical pain threshold were observed before treatment and 7 days into treatment; after the treatment, the expressions of mRNA and protein of Beclin-1 in spinal dorsal horn were detected by real-time fluorescence quantitative PCR and immunohistochemistry; the expression of GRP78 protein in spinal dorsal horn was detected by Western blot method; the autophagosomes and ultrastructure in spinal dorsal horn neurons were observed by electron microscope.@*RESULTS@#After the treatment, compared with the sham operation group, in the model group, the gait score was increased and the mechanical pain threshold was decreased (P<0.01), and the expression of GRP78 protein in spinal dorsal horn was increased (P<0.01). Compared with the model group and the wheat-grain moxibustion+3-MA group, in the wheat-grain moxibustion group, the gait score was decreased and mechanical pain threshold was increased (P<0.01), and the expression of GRP78 protein in spinal dorsal horn was decreased, and the expressions of mRNA and protein of Beclin-1 were increased (P<0.01). Under electron microscope, the ultrastructure of spinal dorsal horn neurons in the wheat-grain moxibustion group was not significantly damaged, and its structure was basically close to normal, and the number of autophagosomes was more than the other three groups.@*CONCLUSION@#Wheat-grain moxibustion at "Dazhui" (GV 14) has analgesic effect on CSR rats. The mechanism may be related to moderately up-regulate the expression of Beclin-1, enhance autophagy and reduce endoplasmic reticulum stress.

Analgesic Effects of Two Types of Spinal Manipulation in Acute Lumbar Radiculopathy Model Rats / 中国结合医学杂志

OBJECTIVE@#To compare the analgesic effects of two types of spinal manipulation (SM) in acute lumbar radiculopathy (ALR) model rats induced by self-transplantation of autologous nucleus pulposus (ANP), and clarify the therapeutic mechanism.@*METHODS@#Totally 108 male Sprague-Dawley rats were randomly divided into 6 groups by a random number table (18 rats in each group), including a blank group with no interference, a sham operation group with a surgery by making a local soft tissue incision on the left side of L5-6 vertebral segment, a model group with ALR of L5 extraforaminal nerve by ANP self-transplantation without other interference, a sham manipulation (SMA) group with simulating physical rotation, as well as a mobilization (MOB) group with simulating low-velocity and variable-amplitude rotation and a manipulation (MAN) group with simulating high-velocity and low-amplitude rotation. The interventions in SMA, MOB, and MAN groups started 1 day after modeling followed by another 5 treatments at days 3, 5, 8, 10 and 12. Rats in the other 3 groups did not receive any special intervention. Behavioral pain tests of 50% mechanical pain withdrawal threshold (50% PWT) and paw withdrawal latency (PWL) were conducted 1 day before operation followed by another 10 tests on days 1-7, 10, 12 and 14. Immunohistochemical expression of nitric oxide synthase (NOS) was investigated on days 5 and 12 after operation.@*RESULTS@#After 3 experimental SM interventions, 50% PWT and PWL were higher in the MAN group than the SMA group on days 6 and 7, and higher on days 10, 12 and 14 postoperatively (P<0.05 or P<0.01), while the same indices were significantly higher in the MOB group than MAN group on days 1-4 (P<0.05 or P<0.01). The expression of NOS was lower in the MAN and MOB groups than SMA group on day 12 postoperatively (P<0.01).@*CONCLUSIONS@#Both manipulation and mobilization produced better results than sham interference in relieving pain by reducing neuroinflammation possibly. At the early period, compared with manipulation, mobilization presented less sensitive response to pain until later visit. SM may inhibit the overexpression of NOS, thereby alleviating severe radiculopathy.

Experience in treatment of cervical spondylotic radiculopathy by relaxing the sinew of hand three / 中国针灸

The clinical experience of professor

La vena varicosa epidural imita el prolapso de disco y causante de un dolor radicular severo: Reporte de un caso / Epidural varicose vein mimic disc prolapse and causing a severe radicular pain: A case report

Venous varicose of epidura is considered a rare cause of nerve root and thecal sac compression and impingement that leads to lower limb radiculopathy. The purpose of this study is to draw attention to this problem during operation. It also aims to focus shed a light on using magnetic resonance imaging (MRI) before the operation. This research also attempts to evaluate the outcome of the surgery. Symptoms of epidural varicose with radiculopathy are rare and the diagnosis is often inaccurate by preoperative clinical examination and radiology investigations. Thus, in many cases the diagnosis is made intra- operatively. The case was a 40 years old female who consulted our outpatient clinic complaining from acute radicular pain in the lower back and down of her right lower limb. MRI was done for her and showed paracentral disc herniation. Intra operatively, an abnormal dilatation of epidural vein impingement on L4 nerve root with no foraminal stenosis was seen. We initiated a thermo coagulation of the epidural vein from proximal to distal ends at disc level and used gel foam patch to control bleeding that was removed all at the end of operation. Then, coagulation ablation was performed. The operation resulted in relief of symptoms and neurologic recovery occurred during follow up period. According to our case and previously published case reports, the outcome is good with recovery of neurological signs and symptoms that can be obtained by coagulation ablation of epidural varicose vein.

Acupoint selection rules of acupuncture for cervical spondylotic radiculopathy based on data mining / 中国针灸

OBJECTIVE@#To analyze the rules of acupoint selection in the acupuncture treatment of cervical spondylotic radiculopathy by data mining.@*METHODS@#The randomized controlled trials (RCTs) regarding acupuncture for cervical spondylotic radiculopathy published from July 15 of 2009 to July 15 of 2019 were retrieved from databases of CNKI, VIP, Wanfang, SinoMed, PubMed and EMbase. A database was established with Microsoft Excel 2016. The frequency and total effective rate of high-frequency acupoints, meridians and acupoint combinations were analyzed, and the association rules of acupoints and meridians were analyzed by Apriori algorithm.@*RESULTS@#A total of 87 RCTs were included, involving 104 acupoints with a total frequency of 921. Among them, the high-frequency acupoints were cervical Jiaji (EX-B 2, 87 times), Fengchi (GB 20, 70 times), Houxi (SI 3, 54 times), etc. The frequently-used acupoints were mainly distributed in the hand @*CONCLUSION@#It is feasible to explore the acupoint selection and compatibility rules of acupuncture for cervical spondylotic radiculopathy by data mining. This study could provide corresponding reference for clinical treatment.

Guía práctica para el tratamiento intervencionista del síndrome radicular lumbosacro (SRL) / Practical guide for interventional treatment of lumbosacral radicular syndrome (LRS)

Introducción: El Síndrome Radicular Lumbosacro (SRL) es una consulta frecuente de dolor neuropático causado por hernias y protrusiones discales o fenómenos degenerativos de la columna lumbosacra. Las técnicas intervencionistas de tratamiento se indican cuando otras terapéuticas no invasivas no alcanzan alivio satisfactorio. Dentro de ellas, las Inyecciones Epidurales de Corticoides (IEC) y la Radiofrecuencia Pulsada del Ganglio de la Raíz Dorsal (RPGRD) son las más indicadas en nuestro Servicio. No disponemos de guías nacionales para su utilización, basándonos habitualmente en las recomendaciones internacionales. Objetivo: Realizar una revisión bibliográfica que apoye la confección de una guía para la toma de decisiones, en cuanto a los aspectos prácticos de las técnicas disponibles, de manera de aplicarlas obteniendo el máximo beneficio posible, reduciendo al mínimo sus riesgos. Discusión: Se discuten las ventajas y desventajas de los abordajes más utilizados para la aplicación de las IEC, así como los agentes farmacológicos disponibles para este fin. Finalmente, se realiza también una puesta al día de los aspectos técnicos de la RPGRD para el tratamiento del SRL refractario al tratamiento con corticoides epidurales.

Introduction: Lumbosacral Radicular Syndrome (LRS) is a frequent neuropathic pain due to disc herniation, disc protrusions or degenerative changes of the lumbosacral spine. Interventional Pain Management techniques for its treatment are indicated when conservative management fails in provide satisfactory pain relief. Epidural Steroid Injections (ESI) and Pulsed Radiofrequency of the Dorsal Root Ganglion (PRDRG) are the procedures most frequently performed in our Service, for LRS treatment. Since guidelines for its use are lacked in our Country, international recommendations are usually followed. Objectives: The aim of this article is to perform a literature search to give evidence support to National guidelines related to available Interventional Pain Management techniques for LRS treatment, in order to balance risks and benefits of each technique in the decision making process. Discussion: Advantages and disadvantages of the different approaches for ESI are discussed and the pharmacologic aspects of the available agents for its use are summarized. Finally, an update of technical aspects of PRGDR for ESI refractory LRS is performed.

Dismorfia de genitales externos en la población pediátrica / Dysmorphia external genitalia in the pediatric population

El procedimiento estético más común de los genitales femeninos es la reducción de los labios menores (labioplastía). Cada vez son más las niñas y mujeres jóvenes que prestan especial atención a la apariencia estética de sus genitales externos. La causa más común de hipertrofia es probablemente la congénita. Las mujeres afectadas habitualmente sufren vergüenza social y preocupación estética. Existen numerosas técnicas para la corrección quirúrgica en la literatura médica, aunque ningún método es superior a otro. Se presentan dos casos de dismorfia de labios menores en adolescentes. En un caso, de dismorfia congénita, se utilizó la técnica de reducción en ancho y en largo mediante desepitelización y resección en cuña inferior. Esta asociación proporciona un cierre libre de tensión y asegura una vascularización adecuada del borde del colgajo superior, lo que disminuiría el riesgo de dehiscencia de herida. En el otro caso, secuela de trauma, se reimplantó el labio afectado con resección del tercio distal del mismo. En ambas pacientes los resultados estéticos fueron satisfactorios...

The most common cosmetic procedure of the female genitalia is the labia minora reduction (labiaplasty). There are more and more girls and young women, with special attention to the aesthetic appearance of their external genitalia. The most common cause of hypertrophy is likely to congenital. Affected women usually suffer social shame and aesthetic concerns. There are numerous techniques for surgical correction in the medical literature, although no method is superior to another. Two cases of a minor dysmorphic teen lips are presented. In one case, a congenital dysmorphic, we used the reduction technique in width and in length by epithelialization and lower wedge resection. This partnership provides tension-free closure and ensures proper vascularization of the upper edge flap, which would reduce the risk wound dehiscence. In the other case, sequel to trauma, the affected lip were treated with resection of the distal portion. In both patients the aesthetic results were satisfactory...

Injeções epidurais de esteroides no tratamento da dor lombar / Steroid epidural injections in the treatment of lumbosacral pain

Contexto: Injeções de corticosteróides no espaço epidural (IEE) fazem parte do arsenal terapêutico no tratamento da dor lombossacral associada à radiculopatia, e sua utilização é crescente em todo o mundo. Objetivo: Revisão dos principais aspectos referentes ao tema, como indicações e contra indicações, eficácia, forma de uso (interlaminar, transforaminal ou sacral), drogas a serem utilizadas e complicações. Método: Pesquisa bibliográfica baseada em dados MedLine (National Library of Medicine),abrangendo o período de 1980 a 2008. As palavras-chave utilizadas foram epidural, steroid injection, lumbar or lumbosacral. Os artigos foram avaliados pelos resumos, selecionando-se também revisões bibliográficas e trabalhos pertinentes ao texto. Realizou-se, além disso, pesquisa manual de eventuais referências cruzadas relevantes de artigos selecionados não encontrados na base de dados e em livros-texto sobre o assunto. Conclusão: A injeção de esteróide no espaço epidural é uma alternativa terapêutica importante no tratamento da dor lombossacral associada à radiculopatia. Novos estudos bem desenhados com diagnósticos clínico e radiológico mais precisos, posologias e técnicas padronizadas podem auxiliar na seleção de subgrupos de pacientes que mais se beneficiarão com o procedimento.

Comparison of epidural steroid injections with conservative management in patients with lumbar radiculopathy

To determine the difference in short- and long-term pain improvement between lumbar Epidural Steroid Injections [ESIs] and conservative management in patients with lumbar radiculopathy. Quasi-experimental study. The Postgraduate Medical Institute of Hayatabad Medical Complex, Peshawar, from April 2005 to March 2007. Fifty elective patients fulfilling the inclusion criteria were randomly divided into two groups. Patients in the steroid group were treated with 80 mg of methylprednisolone injected in combination with 3 ml of 2% plain xylocaine and 3 ml of normal saline in the lumbar epidural space, while patients in the conservative group were treated with bed rest, non-steroidal anti-inflammatory agents, muscle relaxants, and opioids. All the 50 patients in the two groups were regularly assessed at 2 weeks, 1 month, 3 months and 6 months of periods for pain score by the Visual Analogue Scale [VAS], patients satisfaction score and any unwanted side effects. A marked improvement of the pain score and patients satisfaction score were noticed in the steroid group. Less significant improvement was seen in the conservative group during the initial period i.e 2 weeks and 1 month [p <0.05]. The difference in Visual Analogue Scale [VAS] and patients satisfaction score was non-significant in chronic stages of treatment in both groups [p > 0.05]. Epidural steroid injections in acute symptoms of sciatica are considered to be a better option compared to conservative treatment

Intervertebral disc a source of pain? Low back pain: problems and future directions - case reports

The objective of this article is to provide evidence supporting the idea that intervertebral disc is a source of low back pain. Diagnostic tests currently available for diagnosis of a painful disc are inadequate. Treatment protocols for low back pain generally ignore the presence of a painful disc. Pathological processes that may be responsible for discogenic pain are incompletely understood. Without diagnosis and treatment, disc disruption evolves to advanced stages of spinal dysfunction. New treatment modalities are becoming available which if applied early may stop disc disruption. We describe here two case reports where discogenic nature of patients' symptoms was suspected based on patients' history, MRI findings and discography. We highlight the inadequacies of spinal imaging and discography in detecting at painful disc. A treatment [Intradiscal electrothermal therapy] was then directed exclusively to the intervertebral discs. We provide arguments that link discal therapy to resolution of patients' symptoms. Resolution of patients' symptoms after the discal treatment raised our suspicion that pain emanated from the intervertebral discs. Intervertebral disc is a source of low back pain that is often ignored. No diagnostic test currently exists that can reliably confirm presence of a painful disc. Early diagnosis and treatment of a painful disc may reduce enormous pain and suffering from low back pain

La electroacupuntura en el tratamiento de la radiculitis lumbosacra: evaluación electrofisiológica de los resultados / Electroacupuncture in the treatment of lumbosacral radiculitis: electrophysiological assessment of results

Se presentan los resultados de la aplicación de electroacupuntura a 40 pacientes con radiculitis lumbosacra. Se obtuvo una significativa mejoría con el tratamiento, lo que permitió a los pacientes mejorar su disposición y capacidad para el trabajo, disminuir o eliminar la necesidad de medicamentos y lograr su reincorporación social de manera satisfactoria. Se analiza el valor del electromiograma en la evaluación terapeútica de esta afección